‘Big Mouth’ Final Season: 25 Guest Stars Revealed & First Look!

By Bradley Stern |

Mar 20, 2025

Big Mouth is coming back for the final time, and they’re bringing along a ton of talent!

The hit animated series returns to Netflix on May 23 with Season 8.

Here’s a synopsis: “In the eighth and final season of Big Mouth, our beloved Bridgeton teens tackle new challenges as high schoolers such as: driving, drugs, sexual inexperience, enthusiastic consent, p–n and the teenage mind, cancel culture, their changing bodies, and (in the end) fear of the looming future. Through it all, friendship is the cornerstone for surviving this time of life – whether one’s puberty is just beginning, like for Nick who gets his first growth spurt, or near its conclusion, like for a maturing (and prematurely balding) Andrew.”

Keep reading to find out more…

“At the height of the season, when many of our characters are in crisis, Compassion (personified as a new creature voiced by Holly Hunter), emerges as a crucial way forward. Ultimately, though, this season is about the importance of sticking by and supporting your friends, especially when life gets overwhelming and messy. In the end, our kids step into the harrowing unknown of the future, made less afraid of what’s to come because they have each other.”

Series Regulars returning include Nick Kroll, John Mulaney, Jessi Klein, Jason Mantzoukas, Ayo Edebiri, Maya Rudolph, Fred Armisen, Andrew Rannells, and Jordan Peele.